Across TCGA cell cohorts, PSMB11 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PSMB11-associated genes across cancer lineages are LILRA1, RGR, and CLRN1. Each is linked with PSMB11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMB11-to-partner and partner-to-PSMB11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMB11→partner) and Y-score (partner→PSMB11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	LILRA1 →	+0.013	+5.087	<.001	.004	3	1
URINARY_TRACT	RGR →	+0.006	+5.087	<.001	.004	3	1
URINARY_TRACT	CLRN1 →	+0.033	+5.087	<.001	.004	3	1
URINARY_TRACT	MRGPRX1 →	+0.210	+5.087	<.001	.004	3	1
LARGE_INTESTINE	OR4F21 →	+0.171	+2.878	<.001	.009	3	1
LARGE_INTESTINE	CEACAM20 →	+0.111	+3.548	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

PSMB11 survival (RNA) · tumor vs normal (RNA) · all PSMB11 data types