PSMA6

Across TCGA patient cohorts, PSMA6 mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMA6-associated genes across cancer lineages are RNA5SP461, RNU1-96P, and RNU6-1082P. Each is linked with PSMA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMA6-to-partner and partner-to-PSMA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP461 grouped by PSMA6-low versus PSMA6-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMA6→partner) and Y-score (partner→PSMA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP461 →	+0.247	+7.954	<.001	.008	3	2
HNSC	RNU1-96P →	+0.169	+7.954	<.001	.008	3	1
UCEC	RNU6-1082P →	+0.696	+5.136	<.001	<.001	3	1
UCEC	RNA5SP109 →	+0.465	+5.137	<.001	.003	3	1
UCEC	RNU6-316P →	+0.438	+4.538	<.001	.006	3	1
UCEC	RNU6-192P →	+0.736	+4.267	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

RNA5SP461 by PSMA6 expression — HNSC

Explore this box plot interactively →