PSMA6

Across TCGA pan-cancer cohorts, PSMA6 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PSMA6 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PSMA6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PSMA6 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

UVM, HNSC, and SCLC are the cancer types where PSMA6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	II,III,IV	0.253	0.847	<.001	88	view →
HNSC	OS	Tertile	III,IV	0.551	0.745	<.001	81	view →
SCLC	DFS	Tertile	III,IV	0.214	0.700	<.001	53	view →
ACC	DFS	Median	All	0.228	0.644	<.001	44	view →
BLCA	OS	Median	II,III,IV	0.663	0.771	.011	37	view →
KIRC	DFS	Median	All	0.747	0.511	<.001	32	view →
PAAD	OS	Quartile	All	0.288	0.564	.002	29	view →
KICH	DFS	Quartile	II,III,IV	0.483	0.925	.008	28	view →
LIHC	OS	Median	All	0.720	0.825	.007	23	view →
COAD	OS	Median	IV	0.343	0.706	.002	19	view →
KIRP	DFS	Median	All	0.867	0.950	.002	18	view →
SKCM	OS	Median	All	0.374	0.300	.022	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PSMA6–UVM (DFS)

Open the UVM breakdown →