PSMA6

Across TCGA cell cohorts, PSMA6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,819 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PSMA6-associated GO terms across cancer lineages are Mitochondrial tRNA 5'-end processing, Mitochondrial RNA 5'-end processing, and Pericentric heterochromatin formation. Each is linked with PSMA6 in more than 11 cancer types. Because this analysis shows association rather than direction, both PSMA6-to-partner and partner-to-PSMA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial tRNA 5'-end processing grouped by PSMA6-low versus PSMA6-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMA6→partner) and Y-score (partner→PSMA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Mitochondrial tRNA 5'-end processing →	+0.111	+0.581	<.001	<.001	3	12
BLOOD_Lymphoma	Mitochondrial RNA 5'-end processing →	+0.113	+0.738	<.001	.004	3	10
KIDNEY	Pericentric heterochromatin formation →	+0.160	+0.511	.001	.001	2	10
BLOOD_Lymphoma	tRNA wobble cytosine modification →	+0.045	+0.624	.004	.004	3	9
LUNG_SCLC	Actin filament fragmentation →	+0.123	+0.400	<.001	.003	3	8
SKIN	DAMP biosynthetic process →	+0.133	+0.533	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,819 associations by consensus.

Mitochondrial tRNA 5'-end processing by PSMA6 expression — BONE

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