PSMA4

Across TCGA patient cohorts, PSMA4 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMA4-associated genes across cancer lineages are ACVRL1, Ku80, and PKC-b-II_pS660. Each is linked with PSMA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMA4-to-partner and partner-to-PSMA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by PSMA4-low versus PSMA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMA4→partner) and Y-score (partner→PSMA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.139	-2.986	.042	.035	3	1
UCEC	Ku80 →	+0.299	+2.335	.011	.020	3	1
UCEC	PKC-b-II_pS660 →	-0.281	-2.321	.043	.035	3	1
UCEC	Annexin-1 →	+0.652	+2.827	.013	.035	3	1
UCEC	Rictor_pT1135 →	-0.118	-2.321	.022	.035	3	1
UCEC	Tuberin →	+0.474	+2.321	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ACVRL1 by PSMA4 expression — UCEC

Explore this box plot interactively →