PSMA3

Across TCGA patient cohorts, PSMA3 mutation is significantly associated with the RNA expression of many other genes, with 334 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMA3-associated genes across cancer lineages are MIR6853, MIR4689, and MIR5696. Each is linked with PSMA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMA3-to-partner and partner-to-PSMA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6853 grouped by PSMA3-low versus PSMA3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMA3→partner) and Y-score (partner→PSMA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6853 →	+0.242	+8.057	<.001	.005	3	1
UCEC	MIR4689 →	+0.305	+2.548	<.001	.007	3	1
UCEC	MIR5696 →	+0.232	+3.008	<.001	.007	3	1
UCEC	MIR4539 →	+0.665	+1.911	.006	.007	3	1
UCEC	LINC01764 →	+0.353	+2.121	.009	.006	3	1
UCEC	ZNF114-AS1 →	+0.338	+2.350	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 334 associations by consensus.

MIR6853 by PSMA3 expression — BRCA

Explore this box plot interactively →