PSMA3-AS1

Across TCGA pan-cancer cohorts, PSMA3-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PSMA3-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher PSMA3-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PSMA3-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and BRCA show a favorable association.

KICH, ACC, and BLCA are the cancer types where PSMA3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	III,IV	0.280	1.000	.003	88	view →
ACC	OS	Median	All	0.377	0.790	<.001	87	view →
BLCA	DFS	Tertile	II,III,IV	0.706	0.535	.003	67	view →
BRCA	OS	Tertile	III,IV	0.916	0.728	<.001	44	view →
UVM	DFS	Tertile	III,IV	0.241	0.797	.004	39	view →
COAD	DFS	Quartile	All	0.308	0.730	.001	36	view →
HNSC	OS	Median	All	0.801	0.703	.004	30	view →
MESO	DFS	Tertile	II,III,IV	0.449	0.257	.009	24	view →
PRAD	DFS	Tertile	All	0.721	0.897	<.001	24	view →
STAD	OS	Tertile	III,IV	0.635	0.307	.008	21	view →
KIRC	DFS	Tertile	II,III,IV	0.368	0.587	.010	20	view →
LGG	DFS	Median	All	0.789	0.869	.001	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PSMA3-AS1–KICH (DFS)

Open the KICH breakdown →