PSMA2

Across TCGA patient cohorts, PSMA2 mutation is significantly associated with the RNA expression of many other genes, with 1,800 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMA2-associated genes across cancer lineages are RNU1-57P, MIR6075, and MIR592. Each is linked with PSMA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMA2-to-partner and partner-to-PSMA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-57P grouped by PSMA2-low versus PSMA2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMA2→partner) and Y-score (partner→PSMA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU1-57P →	+0.252	+6.040	<.001	.001	3	2
UCEC	MIR6075 →	+0.206	+2.135	.006	.004	3	2
KIRP	MIR592 →	+0.245	+4.928	<.001	.005	3	2
KIRP	C4A-AS1 →	+0.040	+4.187	<.001	.009	3	2
BLCA	USP17L4 →	+0.046	+7.203	<.001	<.001	3	2
BLCA	RNU6-528P →	+0.336	+5.444	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,800 associations by consensus.

RNU1-57P by PSMA2 expression — BLCA

Explore this box plot interactively →