PSMA2

Across TCGA pan-cancer cohorts, PSMA2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PSMA2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PSMA2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PSMA2 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where PSMA2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMA2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.573	<.001	11	view →
KIRC	Male	II,III,IV	+0.366	<.001	11	view →
BLCA	All	All	+0.597	<.001	10	view →
STAD	All	II,III,IV	+0.760	<.001	7	view →
KICH	Female	All	−0.839	<.001	6	view →
READ	Male	All	+0.780	.004	6	view →
BRCA	All	III,IV	+0.517	<.001	6	view →
LUAD	All	All	+0.279	<.001	5	view →
LUSC	Male	All	+0.480	<.001	4	view →
LIHC	Male	All	+0.399	<.001	4	view →
ESCA	All	All	+0.906	.001	2	view →
CHOL	All	All	+0.587	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PSMA2–HNSC

Open the HNSC breakdown →