PSG8

Across TCGA patient cohorts, PSG8 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSG8-associated genes across cancer lineages are Cyclin-B1, STAT3_pY705, and JNK2. Each is linked with PSG8 in more than 3 cancer types. Because this analysis shows association rather than direction, both PSG8-to-partner and partner-to-PSG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PSG8-low versus PSG8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSG8→partner) and Y-score (partner→PSG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.819	+3.000	.001	.036	3	4
SKCM	STAT3_pY705 →	-0.206	-2.425	.034	.017	3	3
UCEC	JNK2 →	+0.197	+2.584	.033	.011	3	2
UCEC	TFRC →	+0.523	+2.584	.034	.011	3	2
UCEC	Tuberin →	+0.325	+2.331	.009	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.628	+2.189	.023	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Cyclin-B1 by PSG8 expression — UCEC

Explore this box plot interactively →