PSG8

Across TCGA pan-cancer cohorts, PSG8 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PSG8’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PSG8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PSG8 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

THCA, KICH, and BLCA are the cancer types where PSG8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSG8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	+0.735	<.001	7	view →
KICH	Female	All	+0.108	.003	3	view →
BLCA	All	All	+0.036	.039	2	view →
LUAD	All	All	+0.035	.017	2	view →
BRCA	All	III,IV	−0.026	.001	2	view →
HNSC	All	All	+0.016	.034	1	view →
LUSC	Female	All	+0.010	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PSG8–THCA

Open the THCA breakdown →