PSG8

Across TCGA cell cohorts, PSG8 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PSG8-associated genes across cancer lineages are SPANXN4, GALNTL5, and TSPAN16. Each is linked with PSG8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSG8-to-partner and partner-to-PSG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPANXN4 grouped by PSG8-low versus PSG8-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSG8→partner) and Y-score (partner→PSG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SPANXN4 →	+0.107	+4.867	<.001	.009	3	1
LUNG_NSCLC_LUAD	GALNTL5 →	+0.052	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	TSPAN16 →	+0.066	+4.157	<.001	.003	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OTOP1 →	+0.013	+4.215	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR10G7 →	+0.009	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

SPANXN4 by PSG8 expression — BLOOD_Lymphoma

Explore this box plot interactively →