PSG11

Across TCGA patient cohorts, PSG11 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSG11-associated genes across cancer lineages are MAPK_pT202_Y204, ASNS, and JNK_pT183_Y185. Each is linked with PSG11 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSG11-to-partner and partner-to-PSG11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by PSG11-low versus PSG11-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSG11→partner) and Y-score (partner→PSG11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MAPK_pT202_Y204 →	-0.371	-2.115	.019	.018	3	2
LUAD	ASNS →	+0.493	+2.700	.010	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.228	-2.584	.001	.010	3	2
UCEC	Ku80 →	+0.262	+2.820	.011	.001	3	2
UCEC	STAT3_pY705 →	-0.448	-1.874	<.001	.049	3	2
LUAD	Akt_pS473 →	-0.383	-2.584	.013	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

MAPK_pT202_Y204 by PSG11 expression — LUAD

Explore this box plot interactively →