PSG11

Across TCGA cell cohorts, PSG11 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PSG11-associated genes across cancer lineages are MMP20, DIRC1, and OR4A16. Each is linked with PSG11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSG11-to-partner and partner-to-PSG11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP20 grouped by PSG11-low versus PSG11-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSG11→partner) and Y-score (partner→PSG11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MMP20 →	+0.059	+4.044	<.001	.009	3	1
LUNG_SCLC	DIRC1 →	+0.040	+4.643	<.001	.004	3	1
LUNG_SCLC	OR4A16 →	+0.026	+4.817	<.001	.001	3	1
LUNG_SCLC	KCNK18 →	+0.328	+4.817	<.001	.001	3	1
SKIN	OR2M5 →	+0.016	+4.437	<.001	.004	3	1
SKIN	OR52A1 →	+0.052	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MMP20 by PSG11 expression — LUNG_SCLC

Explore this box plot interactively →