Across TCGA patient cohorts, PSENEN RNA expression is significantly associated with the protein abundance of many other proteins, with 8,558 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PSENEN-associated proteins across cancer lineages are ACTR2_T117, SPINT2, and FBXW9. Each is linked with PSENEN in more than 3 cancer types. Because this analysis shows association rather than direction, both PSENEN-to-partner and partner-to-PSENEN results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PSENEN→partner) and Y-score (partner→PSENEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ACTR2_T117 →	-0.365	-0.428	.002	<.001	3	4
OV	SPINT2 →	+0.747	+0.630	<.001	<.001	3	4
UCEC	FBXW9 →	+0.413	+0.641	<.001	<.001	3	4
UCEC	IFT74 →	+0.324	+0.756	<.001	<.001	3	4
COAD	ZNRD2 →	+0.247	+0.413	.002	.003	3	3
LSCC	ASAP1 →	-0.216	-0.494	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,558 associations by consensus.

Exploration

PSENEN survival (RNA) · tumor vs normal (RNA) · all PSENEN data types