Across TCGA patient cohorts, PSENEN mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PSENEN-associated genes across cancer lineages are LINC02622, VN1R92P, and RPL26P29. Each is linked with PSENEN in more than 1 cancer types. Because this analysis shows association rather than direction, both PSENEN-to-partner and partner-to-PSENEN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSENEN→partner) and Y-score (partner→PSENEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC02622 →	+0.061	+5.685	<.001	.003	3	1
BLCA	VN1R92P →	+0.061	+6.444	<.001	.001	3	1
SKCM	RPL26P29 →	+0.211	+4.249	<.001	<.001	3	1
SKCM	GAPDHP51 →	+0.092	+2.741	<.001	.001	3	1
SKCM	FAUP2 →	+0.103	+2.254	<.001	.007	3	1
SKCM	MIR2053 →	+0.094	+4.351	.008	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

Exploration

PSENEN survival (RNA) · tumor vs normal (RNA) · all PSENEN data types