Across TCGA patient cohorts, PSENEN mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PSENEN-associated genes across cancer lineages are PKC-a_pS657 and PKC-a. Each is linked with PSENEN in more than 1 cancer types. Because this analysis shows association rather than direction, both PSENEN-to-partner and partner-to-PSENEN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSENEN→partner) and Y-score (partner→PSENEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PKC-a_pS657 →	-0.470	-3.169	.025	.019	1	1
SKCM	PKC-a →	-0.473	-3.169	.032	.019	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Exploration

PSENEN survival (RNA) · tumor vs normal (RNA) · all PSENEN data types