Across TCGA cell cohorts, PSENEN RNA expression is significantly associated with the go_rna of many other GO terms, with 3,270 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PSENEN-associated GO terms across cancer lineages are Positive regulation of endopeptidase activity, Mitotic nuclear membrane organization, and Mitotic nuclear membrane reassembly. Each is linked with PSENEN in more than 18 cancer types. Because this analysis shows association rather than direction, both PSENEN-to-partner and partner-to-PSENEN results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PSENEN→partner) and Y-score (partner→PSENEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of endopeptidase activity →	+0.306	+1.224	<.001	<.001	3	19
URINARY_TRACT	Mitotic nuclear membrane organization →	+0.099	+1.048	<.001	<.001	3	13
URINARY_TRACT	Mitotic nuclear membrane reassembly →	+0.099	+1.048	<.001	<.001	3	13
SOFT_TISSUE	Mitochondrial tRNA pseudouridine synthesis →	-0.150	-1.004	<.001	<.001	3	11
LIVER	Positive regulation of peptidase activity →	+0.227	+1.141	.001	.001	3	11
URINARY_TRACT	COPII-coated vesicle budding →	+0.090	+1.116	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,270 associations by consensus.

Exploration

PSENEN survival (RNA) · tumor vs normal (RNA) · all PSENEN data types