PSEN2

Across TCGA patient cohorts, PSEN2 protein abundance is significantly associated with the RNA expression of many other genes, with 5,008 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PSEN2-associated genes across cancer lineages are KLC1, FAM118B, and EDIL3-DT. Each is linked with PSEN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSEN2-to-partner and partner-to-PSEN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PSEN2 versus KLC1 in BRCA, with a Pearson correlation of -0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSEN2→partner) and Y-score (partner→PSEN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KLC1 →	-0.419	-0.577	.003	.003	3	3
BRCA	FAM118B →	-0.488	-0.479	<.001	.002	3	3
GBM	EDIL3-DT →	-0.421	-0.377	<.001	<.001	3	3
LSCC	ANXA1 →	-1.129	-0.481	<.001	<.001	3	3
BRCA	LINC01703 →	+0.631	+0.464	.007	.003	3	3
UCEC	FTH1P25 →	+0.515	+0.666	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,008 associations by consensus.

PSEN2 vs KLC1 — BRCA

Explore this scatter interactively →