PSEN1

Across TCGA pan-cancer cohorts, PSEN1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PSEN1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PSEN1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PSEN1 is over-expressed in tumor.

HNSC, LUAD, and COAD are the cancer types where PSEN1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSEN1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.532	<.001	12	view →
LUAD	Female	III,IV	+0.663	<.001	9	view →
COAD	Male	II,III,IV	+0.246	.014	6	view →
LSCC	Male	All	+0.194	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PSEN1–HNSC

Open the HNSC breakdown →