PSEN1

Across TCGA patient cohorts, PSEN1 mutation is significantly associated with the RNA expression of many other genes, with 1,032 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSEN1-associated genes across cancer lineages are RNU6-150P, MIR378E, and ATP6V1E1P2. Each is linked with PSEN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSEN1-to-partner and partner-to-PSEN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-150P grouped by PSEN1-low versus PSEN1-high in DLBC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSEN1→partner) and Y-score (partner→PSEN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	RNU6-150P →	+0.884	+4.874	<.001	.008	3	2
BLCA	MIR378E →	+0.320	+5.033	.001	.003	3	2
UCEC	ATP6V1E1P2 →	+0.211	+2.376	<.001	<.001	3	2
CESC	RNU4-31P →	+0.266	+4.874	<.001	.002	3	2
CESC	RNU6-14P →	+0.257	+4.669	<.001	.007	3	2
CESC	RNA5SP198 →	+0.224	+5.144	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,032 associations by consensus.

RNU6-150P by PSEN1 expression — DLBC

Explore this box plot interactively →