PSEN1

Across TCGA cell cohorts, PSEN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,244 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PSEN1-associated GO terms across cancer lineages are Protein catabolic process at synapse, Protein catabolic process at postsynapse, and Positive regulation of amyloid fibril formation. Each is linked with PSEN1 in more than 19 cancer types. Because this analysis shows association rather than direction, both PSEN1-to-partner and partner-to-PSEN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein catabolic process at synapse grouped by PSEN1-low versus PSEN1-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PSEN1→partner) and Y-score (partner→PSEN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Protein catabolic process at synapse →	+0.191	+0.744	<.001	<.001	3	20
BLOOD_Lymphoma	Protein catabolic process at postsynapse →	+0.191	+0.744	<.001	<.001	3	20
STOMACH	Positive regulation of amyloid fibril formation →	+0.256	+1.058	<.001	<.001	3	17
OVARY	Process utilizing autophagic mechanism →	+0.059	+0.824	<.001	<.001	3	17
OVARY	Autophagy →	+0.059	+0.824	<.001	<.001	3	17
STOMACH	Astrocyte activation involved in immune response →	+0.165	+0.570	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,244 associations by consensus.

Protein catabolic process at synapse by PSEN1 expression — BLOOD_Lymphoma

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