PSD4

Across TCGA patient cohorts, PSD4 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSD4-associated genes across cancer lineages are Notch1, Shc_pY317, and PDK1_pS241. Each is linked with PSD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSD4-to-partner and partner-to-PSD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PSD4-low versus PSD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSD4→partner) and Y-score (partner→PSD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.120	+1.775	.010	.007	3	2
UCEC	Shc_pY317 →	-0.162	-1.765	.001	.013	3	2
SKCM	PDK1_pS241 →	-0.126	-1.304	.022	.028	3	2
UCEC	ER-alpha_pS118 →	-0.256	-1.321	.033	.029	3	1
UCEC	ACC1 →	+0.301	+1.598	.013	.040	3	1
UCEC	JNK_pT183_Y185 →	-0.148	-1.571	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Notch1 by PSD4 expression — UCEC

Explore this box plot interactively →