PSD4

Across TCGA cell cohorts, PSD4 mutation is significantly associated with the RNA expression of many other genes, with 399 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PSD4-associated genes across cancer lineages are OR2T10, KRTAP17-1, and CHRNA7. Each is linked with PSD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSD4-to-partner and partner-to-PSD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T10 grouped by PSD4-low versus PSD4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSD4→partner) and Y-score (partner→PSD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR2T10 →	+0.043	+5.369	<.001	.004	3	2
BLOOD_Leukemia	KRTAP17-1 →	+0.848	+3.475	<.001	.006	3	2
LARGE_INTESTINE	CHRNA7 →	+1.085	+3.364	<.001	.002	3	2
LARGE_INTESTINE	SHANK3 →	+0.990	+3.451	<.001	.002	3	2
SOFT_TISSUE	OBP2A →	+0.410	+5.369	.005	.004	3	1
SOFT_TISSUE	KRT73 →	+0.162	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 399 associations by consensus.

OR2T10 by PSD4 expression — SOFT_TISSUE

Explore this box plot interactively →