PSCA

Across TCGA pan-cancer cohorts, PSCA Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated PSCA data layer compared with 28 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PSCA Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PSCA expression acts as an unfavorable survival marker.

HNSC are the cancer types where PSCA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.029	0.743	<.001	42	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

PSCA–HNSC (OS)

Open the HNSC breakdown →