PSCA

Across TCGA pan-cancer cohorts, PSCA RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PSCA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PSCA RNA is repressed in tumor relative to normal tissue. In most cancer types PSCA is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where PSCA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSCA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−2.291	<.001	12	view →
HNSC	All	IV	−3.259	<.001	11	view →
KIRP	Male	II,III,IV	−2.169	<.001	9	view →
LIHC	All	All	+0.325	<.001	7	view →
BRCA	All	II,III,IV	+1.148	<.001	6	view →
PAAD	All	All	+7.065	.003	2	view →
PRAD	All	All	−1.182	.016	2	view →
CHOL	All	All	+0.935	<.001	2	view →
ESCA	All	All	−2.980	.013	1	view →
STAD	All	II,III,IV	−2.387	.047	1	view →
LUAD	All	II,III,IV	+1.190	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PSCA–KIRC

Open the KIRC breakdown →