PSCA

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PSCA protein abundance is significantly associated with the RNA expression of many other genes, with 2,950 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PSCA-associated genes across cancer lineages are KRT23, PLPPR4, and PTH1R. Each is linked with PSCA in more than 2 cancer types. Because this analysis shows association rather than direction, both PSCA-to-partner and partner-to-PSCA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PSCA versus KRT23 in LUAD, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSCA→partner) and Y-score (partner→PSCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADKRT23 →+3.433+1.888.002.00633
LUADPLPPR4 →+0.879+1.421.002<.00132
LUADPTH1R →+0.877+1.826.002.00132
LUADLINC01936 →+0.841+1.420.007<.00132
HNSCALG1L9P →-1.184-1.143<.001<.00132
LUADKCNE1B →+0.242+1.361.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,950 associations by consensus.

PSCA vs KRT23 — LUAD

Per-sample scatter of PSCA vs KRT23 in LUAD (Pearson r = 0.60).

Explore this scatter interactively →

Exploration