PSCA

Across TCGA patient cohorts, PSCA mutation is significantly associated with the RNA expression of many other genes, with 153 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSCA-associated genes across cancer lineages are RNA5SP205, OR6M2P, and RNU6-1216P. Each is linked with PSCA in more than 1 cancer types. Because this analysis shows association rather than direction, both PSCA-to-partner and partner-to-PSCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP205 grouped by PSCA-low versus PSCA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSCA→partner) and Y-score (partner→PSCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP205 →	+0.203	+3.267	.001	.005	3	2
BLCA	OR6M2P →	+0.034	+7.640	<.001	.009	3	1
COAD	RNU6-1216P →	+0.968	+6.122	<.001	.002	3	1
COAD	RNY3P2 →	+0.873	+5.790	<.001	.003	3	1
COAD	RNU6-268P →	+1.241	+5.516	<.001	.004	3	1
COAD	MIR28 →	+0.703	+7.142	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 153 associations by consensus.

RNA5SP205 by PSCA expression — UCEC

Explore this box plot interactively →