PSCA

Across TCGA patient cohorts, PSCA mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSCA-associated genes across cancer lineages are p62 Lck ligand, YAP, and C-Raf_pS338. Each is linked with PSCA in more than 1 cancer types. Because this analysis shows association rather than direction, both PSCA-to-partner and partner-to-PSCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by PSCA-low versus PSCA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSCA→partner) and Y-score (partner→PSCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.718	+3.009	<.001	.019	3	1
UCEC	YAP →	+0.194	+2.817	.025	.036	3	1
UCEC	C-Raf_pS338 →	-0.127	-3.000	.007	.037	3	1
UCEC	EGFR_pY1068 →	-0.336	-3.000	.020	.037	1	1
UCEC	A-Raf_pS299 →	-0.208	-3.000	.002	.037	1	1
UCEC	Ku80 →	+0.382	+3.013	.005	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

p62 Lck ligand by PSCA expression — UCEC

Explore this box plot interactively →