PRXL2C

Across TCGA patient cohorts, PRXL2C mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRXL2C-associated genes across cancer lineages are MIR6864, RNU6-694P, and RNU7-103P. Each is linked with PRXL2C in more than 1 cancer types. Because this analysis shows association rather than direction, both PRXL2C-to-partner and partner-to-PRXL2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6864 grouped by PRXL2C-low versus PRXL2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRXL2C→partner) and Y-score (partner→PRXL2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6864 →	+1.148	+3.324	<.001	.002	3	1
COAD	RNU6-694P →	+0.325	+4.893	<.001	.005	3	1
COAD	RNU7-103P →	+0.479	+4.893	.007	.005	3	1
COAD	RPL23AP68 →	+0.140	+5.942	<.001	<.001	3	1
COAD	IGHVIII-82 →	+0.188	+4.790	.003	.006	3	1
SKCM	RNA5SP409 →	+0.238	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

MIR6864 by PRXL2C expression — UCEC

Explore this box plot interactively →