PRXL2B

Across TCGA patient cohorts, PRXL2B mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PRXL2B-associated genes across cancer lineages are MIR147A, RNU4-88P, and MIR3908. Each is linked with PRXL2B in more than 1 cancer types. Because this analysis shows association rather than direction, both PRXL2B-to-partner and partner-to-PRXL2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR147A grouped by PRXL2B-low versus PRXL2B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRXL2B→partner) and Y-score (partner→PRXL2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR147A →	+0.481	+4.893	.001	.005	3	2
COAD	RNU4-88P →	+0.706	+6.734	<.001	<.001	3	2
SKCM	MIR3908 →	+0.431	+5.970	<.001	.002	3	2
SKCM	OR4F14P →	+0.087	+5.097	<.001	.008	3	2
SKCM	MIR5787 →	+0.593	+5.513	<.001	.004	3	1
SKCM	RFKP2 →	+0.099	+6.199	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

MIR147A by PRXL2B expression — COAD

Explore this box plot interactively →