PRXL2B

Across TCGA cell cohorts, PRXL2B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,564 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PRXL2B-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Protein-containing complex disassembly, and Regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with PRXL2B in more than 11 cancer types. Because this analysis shows association rather than direction, both PRXL2B-to-partner and partner-to-PRXL2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by PRXL2B-low versus PRXL2B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRXL2B→partner) and Y-score (partner→PRXL2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of calcium ion export across plasma membrane →	+0.073	+0.989	.002	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Protein-containing complex disassembly →	+0.073	+0.998	<.001	<.001	3	11
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.203	+1.062	<.001	<.001	3	10
STOMACH	Regulation of tolerance induction dependent upon immune response →	+1.388	+1.698	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of macrophage proliferation →	+0.194	+1.049	.002	<.001	3	10
BONE	Regulation of glucose mediated signaling pathway →	+0.161	+1.445	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,564 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by PRXL2B expression — BONE

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