PRXL2A

Across TCGA patient cohorts, PRXL2A mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRXL2A-associated genes across cancer lineages are FoxM1, LKB1, and PRAS40_pT246. Each is linked with PRXL2A in more than 1 cancer types. Because this analysis shows association rather than direction, both PRXL2A-to-partner and partner-to-PRXL2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by PRXL2A-low versus PRXL2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRXL2A→partner) and Y-score (partner→PRXL2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.209	+2.000	.039	.010	3	1
UCEC	LKB1 →	-0.086	-1.584	.040	.036	3	1
UCEC	PRAS40_pT246 →	+0.151	+2.321	.024	.034	3	1
UCEC	Annexin-1 →	+0.520	+2.189	.011	.034	3	1
UCEC	TAZ →	-0.110	-2.000	.048	.010	3	1
UCEC	Tuberin →	+0.221	+1.584	.037	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

FoxM1 by PRXL2A expression — UCEC

Explore this box plot interactively →