PRXL2A

Across TCGA pan-cancer cohorts, PRXL2A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PRXL2A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PRXL2A RNA is repressed in tumor relative to normal tissue. In most cancer types PRXL2A is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and KIRP are the cancer types where PRXL2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRXL2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−2.609	<.001	11	view →
COAD	Female	All	−0.929	<.001	11	view →
KIRP	All	III,IV	−1.474	<.001	9	view →
THCA	All	IV	−1.122	<.001	9	view →
LUAD	Male	III,IV	+0.891	<.001	9	view →
HNSC	Male	III,IV	+0.839	<.001	9	view →
LUSC	Female	All	+1.252	<.001	8	view →
BRCA	All	III,IV	−1.001	<.001	8	view →
UCEC	All	III,IV	+0.906	.008	6	view →
LIHC	Male	All	+0.672	<.001	5	view →
KIRC	All	All	−0.333	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PRXL2A–KICH

Open the KICH breakdown →