PRUNE1

Across TCGA patient cohorts, PRUNE1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,973 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PRUNE1-associated genes across cancer lineages are GOLPH3L, PEX19, and LYSMD1. Each is linked with PRUNE1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PRUNE1-to-partner and partner-to-PRUNE1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRUNE1 versus GOLPH3L in HNSC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRUNE1→partner) and Y-score (partner→PRUNE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GOLPH3L →	+0.998	+0.411	<.001	<.001	3	7
HNSC	PEX19 →	+0.534	+0.283	<.001	<.001	3	7
LSCC	LYSMD1 →	+0.686	+0.439	<.001	<.001	3	7
LSCC	TADA1 →	+0.653	+0.433	<.001	<.001	3	7
HNSC	KLHL12 →	+1.149	+0.376	<.001	<.001	3	6
LSCC	TARS2 →	+0.608	+0.465	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,973 associations by consensus.

PRUNE1 vs GOLPH3L — HNSC

Explore this scatter interactively →