PRTG

Across TCGA patient cohorts, PRTG mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRTG-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and ATM. Each is linked with PRTG in more than 2 cancer types. Because this analysis shows association rather than direction, both PRTG-to-partner and partner-to-PRTG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PRTG-low versus PRTG-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRTG→partner) and Y-score (partner→PRTG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.501	+3.178	<.001	.010	3	3
UCEC	eEF2 →	+0.282	+1.392	.004	.017	3	3
UCEC	ATM →	-0.399	-2.234	.001	.001	3	3
COAD	ASNS →	+0.799	+3.000	<.001	.035	3	3
UCEC	EGFR_pY1068 →	-0.254	-1.722	<.001	<.001	3	2
UCEC	A-Raf_pS299 →	-0.110	-1.369	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Caspase-7-cleavedD198 by PRTG expression — COAD

Explore this box plot interactively →