PRSS8

Across TCGA patient cohorts, PRSS8 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS8-associated genes across cancer lineages are Annexin-1, JNK2, and p27_pT198. Each is linked with PRSS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS8-to-partner and partner-to-PRSS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by PRSS8-low versus PRSS8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS8→partner) and Y-score (partner→PRSS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.778	+3.189	<.001	.010	3	2
UCEC	JNK2 →	+0.282	+2.179	.001	.034	3	1
UCEC	p27_pT198 →	+0.092	+2.115	.049	.019	3	1
UCEC	p62 Lck ligand →	+0.464	+2.469	.001	.010	3	1
UCEC	P-Cadherin →	-0.143	-2.999	.023	.035	3	1
UCEC	TIGAR →	+0.171	+2.142	.010	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Annexin-1 by PRSS8 expression — UCEC

Explore this box plot interactively →