PRSS8

Across TCGA cell cohorts, PRSS8 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRSS8-associated genes across cancer lineages are MAGEB4, TKTL2, and PPDPFL. Each is linked with PRSS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS8-to-partner and partner-to-PRSS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by PRSS8-low versus PRSS8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS8→partner) and Y-score (partner→PRSS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.016	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	TKTL2 →	+0.050	+4.187	<.001	.002	3	1
LARGE_INTESTINE	PPDPFL →	+0.040	+3.632	<.001	.003	3	1
LARGE_INTESTINE	FAM205A →	+0.020	+3.614	<.001	.006	3	1
LARGE_INTESTINE	OR5M11 →	+0.106	+3.095	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MAGEB4 by PRSS8 expression — LARGE_INTESTINE

Explore this box plot interactively →