PRSS58

Across TCGA patient cohorts, PRSS58 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,380 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PRSS58-associated GO terms across cancer lineages are Protein homooligomerization, Protein stabilization, and Cellular response to oxygen levels. Each is linked with PRSS58 in more than 9 cancer types. Because this analysis shows association rather than direction, both PRSS58-to-partner and partner-to-PRSS58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein homooligomerization grouped by PRSS58-low versus PRSS58-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS58→partner) and Y-score (partner→PRSS58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Protein homooligomerization →	+0.027	+0.126	.001	.004	3	10
UCEC	Protein stabilization →	+0.051	+0.043	<.001	<.001	3	9
UCEC	Cellular response to oxygen levels →	+0.043	+0.041	<.001	<.001	3	9
STAD	Blastocyst development →	+0.037	+0.064	<.001	<.001	3	9
HNSC	Substantia nigra development →	+0.049	+0.008	<.001	<.001	3	9
ESCA	Negative regulation of protein-containing complex assembly →	+0.043	+0.150	<.001	.003	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,380 associations by consensus.

Protein homooligomerization by PRSS58 expression — ESCA

Explore this box plot interactively →