PRSS58

Across TCGA pan-cancer cohorts, PRSS58 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PRSS58 data layer compared with 10 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PRSS58 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PRSS58 expression acts as an unfavorable survival marker, although some lineages such as UCS and COAD show a favorable association.

LUAD, UVM, and ESCA are the cancer types where PRSS58 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	III,IV	0.057	0.680	<.001	54	view →
UVM	OS	Tertile	All	0.248	0.769	.007	36	view →
ESCA	OS	Tertile	All	0.442	1.000	<.001	27	view →
THCA	DFS	Tertile	All	0.787	0.916	.009	27	view →
OV	OS	Tertile	III,IV	0.694	0.851	.010	24	view →
UCS	DFS	Tertile	III,IV	0.851	0.343	.018	24	view →
BRCA	DFS	Tertile	III,IV	0.740	0.888	.007	24	view →
COAD	DFS	Tertile	II,III,IV	0.905	0.722	.008	19	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	18	view →
MESO	OS	Tertile	IV	0.036	0.602	<.001	18	view →
DLBC	DFS	Tertile	III,IV	0.137	0.790	<.001	18	view →
KIRP	DFS	Tertile	All	1.000	0.564	.024	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PRSS58–LUAD (OS)

Open the LUAD breakdown →