PRSS58

Across TCGA patient cohorts, PRSS58 mutation is significantly associated with the RNA expression of many other genes, with 661 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS58-associated genes across cancer lineages are RPSAP40, MIR557, and CEACAMP4. Each is linked with PRSS58 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRSS58-to-partner and partner-to-PRSS58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPSAP40 grouped by PRSS58-low versus PRSS58-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS58→partner) and Y-score (partner→PRSS58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPSAP40 →	+0.023	+1.526	.001	.001	3	3
HNSC	MIR557 →	+0.248	+3.498	<.001	.006	3	2
HNSC	CEACAMP4 →	+0.093	+3.709	<.001	.004	3	2
HNSC	LINC01069 →	+0.033	+4.441	<.001	.005	3	2
HNSC	RNU6ATAC17P →	+0.530	+3.602	<.001	.002	3	2
HNSC	RNU2-58P →	+0.465	+3.369	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 661 associations by consensus.

RPSAP40 by PRSS58 expression — SKCM

Explore this box plot interactively →