PRSS58

Across TCGA patient cohorts, PRSS58 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS58-associated genes across cancer lineages are STAT5a, Caspase-8, and C-Raf. Each is linked with PRSS58 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS58-to-partner and partner-to-PRSS58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT5a grouped by PRSS58-low versus PRSS58-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS58→partner) and Y-score (partner→PRSS58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	STAT5a →	+0.466	+2.602	.021	.005	3	2
UCEC	Caspase-8 →	-0.294	-3.143	.020	.018	3	2
SKCM	C-Raf →	+0.169	+2.247	<.001	.001	3	2
SKCM	Fibronectin →	-0.390	-1.502	.017	.028	3	1
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.409	+1.502	.042	.028	3	1
SKCM	PI3K-p85 →	+0.204	+2.128	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

STAT5a by PRSS58 expression — SKCM

Explore this box plot interactively →