PRSS58

Across TCGA cell cohorts, PRSS58 RNA expression is significantly associated with the mutation status of many other genes, with 156 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible PRSS58-associated genes across cancer lineages are SEMA6C, TRIM46, and USP43. Each is linked with PRSS58 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS58-to-partner and partner-to-PRSS58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMA6C grouped by PRSS58-low versus PRSS58-high in PANCREAS.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS58→partner) and Y-score (partner→PRSS58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SEMA6C →	+5.000	+0.092	.006	<.001	3	2
PANCREAS	TRIM46 →	+5.000	+0.092	.006	<.001	3	2
LUNG_NSCLC_LUSC	USP43 →	+4.643	+0.023	.008	<.001	3	2
CNS	HIP1R →	+3.700	+0.069	.003	<.001	3	2
URINARY_TRACT	CHL1 →	+4.087	+0.102	.009	<.001	3	1
URINARY_TRACT	FASTKD1 →	+5.087	+0.136	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 156 associations by consensus.

SEMA6C by PRSS58 expression — PANCREAS

Explore this box plot interactively →