PRSS58

Across TCGA cell cohorts, PRSS58 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PRSS58-associated genes across cancer lineages are DEFB129, CIB3, and PPP3R2. Each is linked with PRSS58 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS58-to-partner and partner-to-PRSS58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB129 grouped by PRSS58-low versus PRSS58-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS58→partner) and Y-score (partner→PRSS58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DEFB129 →	+0.021	+4.022	<.001	.006	3	1
SKIN	CIB3 →	+0.097	+4.115	.004	.001	3	1
SKIN	PPP3R2 →	+0.015	+3.459	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

DEFB129 by PRSS58 expression — SKIN

Explore this box plot interactively →