Across TCGA pan-cancer cohorts, PRSS55 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PRSS55 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PRSS55 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PRSS55 expression acts as an unfavorable survival marker.

UCEC, LUAD, and SKCM are the cancer types where PRSS55 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	OS	Median	III,IV	0.004	0.662	<.001	6	view →
SKCM	OS	Median	III,IV	0.179	0.721	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: PRSS55 tumor-vs-normal RNA expression · all PRSS55 data types