Across TCGA patient cohorts, PRSS55 mutation is significantly associated with the RNA expression of many other genes, with 1,112 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS55-associated genes across cancer lineages are RCCD1, POLR2L, and DUXAP3. Each is linked with PRSS55 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRSS55-to-partner and partner-to-PRSS55 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS55→partner) and Y-score (partner→PRSS55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RCCD1 →	+0.430	+2.523	.002	.001	3	3
UCEC	POLR2L →	+0.484	+3.180	.008	<.001	3	3
READ	DUXAP3 →	+0.070	+5.681	<.001	.001	3	3
UCEC	OIP5 →	+0.712	+3.601	.003	.001	3	3
UCEC	RPS15 →	+0.487	+2.513	.005	.001	3	3
UCEC	PSMB6 →	+0.429	+3.584	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,112 associations by consensus.

Exploration

PRSS55 survival (RNA) · tumor vs normal (RNA) · all PRSS55 data types