Across TCGA patient cohorts, PRSS55 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS55-associated genes across cancer lineages are EGFR_pY1068, p90 RSK, and FoxM1. Each is linked with PRSS55 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS55-to-partner and partner-to-PRSS55 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS55→partner) and Y-score (partner→PRSS55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.241	-2.459	.023	.019	3	2
UCEC	p90 RSK →	+0.168	+1.713	.038	.027	3	2
LUAD	FoxM1 →	+0.265	+3.182	.031	.009	2	2
LUAD	GATA3 →	+0.153	+2.321	.015	.035	3	1
LUAD	ACC1 →	-0.378	-2.321	.043	.035	3	1
LUAD	Stathmin →	+0.233	+2.841	.004	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

PRSS55 survival (RNA) · tumor vs normal (RNA) · all PRSS55 data types