PRSS53

Across TCGA cell cohorts, PRSS53 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PRSS53-associated genes across cancer lineages are OR10Q1, OR13G1, and MS4A10. Each is linked with PRSS53 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS53-to-partner and partner-to-PRSS53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10Q1 grouped by PRSS53-low versus PRSS53-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS53→partner) and Y-score (partner→PRSS53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR10Q1 →	+0.653	+5.643	<.001	.002	3	1
LARGE_INTESTINE	OR13G1 →	+0.024	+4.415	<.001	.007	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
BLOOD_Leukemia	POTEB →	+0.018	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR10Q1 by PRSS53 expression — LUNG_SCLC

Explore this box plot interactively →