PRSS50

Across TCGA cell cohorts, PRSS50 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRSS50-associated genes across cancer lineages are GYS2, TBC1D3, and PHOX2B. Each is linked with PRSS50 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS50-to-partner and partner-to-PRSS50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GYS2 grouped by PRSS50-low versus PRSS50-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS50→partner) and Y-score (partner→PRSS50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GYS2 →	+0.047	+3.930	<.001	.003	3	1
LARGE_INTESTINE	TBC1D3 →	+0.066	+4.688	<.001	<.001	3	1
BLOOD_Leukemia	PHOX2B →	+0.018	+4.365	<.001	.002	3	1
BLOOD_Leukemia	MYOG →	+0.033	+3.769	.001	.008	3	1
BLOOD_Leukemia	BTBD16 →	+0.067	+3.959	.002	.005	3	1
BLOOD_Leukemia	DCLK3 →	+0.258	+3.769	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

GYS2 by PRSS50 expression — LARGE_INTESTINE

Explore this box plot interactively →