PRSS48

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PRSS48 mutation is significantly associated with the RNA expression of many other genes, with 366 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS48-associated genes across cancer lineages are RN7SKP181, RNF14P2, and RNU6-644P. Each is linked with PRSS48 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRSS48-to-partner and partner-to-PRSS48 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS48→partner) and Y-score (partner→PRSS48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCRN7SKP181 →+0.149+5.182<.001.00733
COADRNF14P2 →+0.277+7.741<.001.00932
CESCRNU6-644P →+0.422+4.193<.001.00932
HNSCLINC02221 →+0.234+5.368<.001.00532
CESCPEBP1P1 →+0.098+4.276<.001.00832
LUADMIR323A →+0.298+7.930<.001.00832
Each partner links to its Q-omics profile. Showing the 6 strongest of 366 associations by consensus.

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